Neuroscience Seminar Series

We are delighted to announce our next Neuroscience Seminar Series talk. Presentations by experts in their field will take place both here at MPINB and via Zoom.

"Sensitive genetically engineered light sensors for tracking a broad-spectrum of physiological neurotransmitter signaling"

Lin Tian - Max Planck Florida Institute for Neuroscience

abstract

To study the neural circuitry, the action of one cell under the context of others, one would precisely measure and perturb specific neuronal populations and molecules in behaving animals who are specifically engaged in performing the computation or function of interest. The dataset of millions of neurons firing together underlying a behavior is required to develop and refine theories (hypotheses) explaining animal behavior in terms of brain physiology. The lab focuses on developing novel genetically encoded indicators based on fluorescence proteins and chemical dyes, especially focusing on direct and specific measurement of myriad input signals with needed spatial and temporal resolutions. In this talk, I will discuss our recent progress in developing genetically encoded indicators for neuromodulators using machine-learning based single-cell screening. I will discuss the design, characterization, and applications of these genetically encoded indicators, especially serotonin probes,for both in vivo imaging and drug discovery. In combination with calcium imaging and optogenetics, these sensors are well poised to permit direct functional analysis of how the spatiotemporal coding of neural input signaling mediates the plasticity and function of target circuits.

In-Person

MPINB Lecture Hall, Ludwig-Erhard-Allee 2, 53175 Bonn

Zoom

https://mpinb-mpg-de.zoom.us/j/63767300567
Meeting-ID: 637 6730 0567

Zur Ãœbersicht